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Science 28 January 1966:
Vol. 151. no. 3709, pp. 473 - 475
DOI: 10.1126/science.151.3709.473
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Articles

Autoimmune Encephalomyelitis and Ocular Lesions in Monkeys Sensitized during the Neonatal Period

S. H. Stone 1, E. M. Lerner II 1, R. E. Myers 1, and W. H. Niemann 1

1 Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, and Laboratory of Perinatal Physiology, National Institute of Neurological Diseases and Blindness, San Juan, Puerto Rico

The neonatal rhesus monkey is susceptible to the induction of autoimmune encephalomyelitis. The disease has been produced regularly by injection of neonatal animals with guinea pig spinal cord antigen in complete Freund's adjuvant. The onset of the disease, as compared with onset in adults, is delayed and is most often heralded by intrinsic eye lesions, notably widespread retinal hemorrhages.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Chronic Relapsing Experimental Allergic Encephalomyelitis: Clinicopathological Comparison With Multiple Sclerosis.
H. Lassmann and H. M. Wisniewski (1979)
Arch Neurol 36, 490-497
   Abstract »    PDF »
Autoimmune Chorioretinitis in Rhesus Monkeys.
E. M. Lerner II, S. H. Stone, R. E. Myers, and L. von Sallmann (1968)
Science 162, 561-562
   Abstract »    PDF »
The Uvea.
S. B. Aronson (1968)
Arch Ophthalmol 79, 490-501
   PDF »
Adoptive Autoimmune Encephalomyelitis in Inbred Guinea Pigs: Immunological and Histological Aspects.
S. H. Stone, E. M. Lerner II, and J. H. Goode (1968)
Science 159, 995-997
   Abstract »    PDF »
Vasculo-occlusive Retinopathy in Experimental Allergic Encephalomyelitis.
L. von Sallmann, R. E. Myers, E. M. Lerner II, and S. H. Stone (1967)
Arch Ophthalmol 78, 112-120
   Abstract »    PDF »
The Uvea.
S. B. Aronson (1967)
Arch Ophthalmol 77, 696-709
   PDF »


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