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Science 28 January 1966:
Vol. 151. no. 3709, pp. 471 - 473
DOI: 10.1126/science.151.3709.471
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Articles

Restoration of Gamma Globulin Production in Agammaglobulinemic Chickens

Max D. Cooper 1, Melvin L. Schwartz 1, and Robert A. Good 1

1 Pediatric Research Laboratories, Variety Club Heart Hospital, University of Minnesota, Minneapolis

Chickens irradiated and bursectomized in the newly hatched period consistently develop agammaglobulinemia and form no circulating antibodies; if the birds are treated immediately after operations by intra-abdominal injection of unirradiated autologous bursa cells, immunoglobulin production, lymphoid germinal centers, and plasma cells are restored; however, the birds fail to produce antibody to specific antigenic challenge.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)