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Science 14 January 1966:
Vol. 151. no. 3707, pp. 219 - 221
DOI: 10.1126/science.151.3707.219
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Articles

Phenylketonuria in Rats: Reversibility of Behavorial Deficit

V. J. Polidora 1, Robert F. Cunningham 2, and Harry A. Waisman 3

1 Department of Psychology, University of Wisconsin, Madison
2 Central Wisconsin Colony and Training School, Madison
3 Department of Pediatrics, University of Wisconsin Medical School

Phenylketonuria was induced in hooded rats by the conventional procedure of feeding excessive quantities of L-phenylalanine after weaning. Although this procedure reliably induced large, dose-dependent deficits in performance on a water maze, the behavioral deficits were completely eliminated after cessation of phenylalanine loading. These results cast doubt on the assumption that this animal preparation adequately simulates the irreversible intellectual impairments found in the child with late-detected phenylketonuria.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Electroencephalographic Effects of L-Phenylalanine in the Cat.
M. P. Nigam, C. W. Watson, and E. M. Marcus (1968)
Arch Neurol 18, 191-195
   Abstract »    PDF »
Aminoacidemias: Effects on Maze Performance and Cerebral Serotonin.
C. M. McKean, S. M. Schanberg, and N. J. Giarman (1967)
Science 157, 213-215
   Abstract »    PDF »
Phenylketonuria: Enduring Behavioral Deficits in Phenylketonuric Rats.
R. L. Schalock and F. D. Klopfer (1967)
Science 155, 1033-1035
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)