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Science 31 December 1965:
Vol. 150. no. 3705, pp. 1830 - 1831
DOI: 10.1126/science.150.3705.1830
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Articles

Succinate: Protective Agent against Hyperbaric Oxygen Toxicity

Aaron P. Sanders 1, I. H. Hall 1, and Barnes Woodhall 1

1 Departments of Radiology and Neurosurgery, Duke University Medical Center, Durham, North Carolina

When succinate is used to protect rats against the toxicity of oxygen at high pressure, 100 percent survive, with normal or above normal concentrations of adenosine triphosphate being present in the cerebral hemisphere, liver, and kidney. In contrast, 90 percent of the nonprotected animals died during exposure. In corresponding tissues of surviving nonprotected animals adenosine triphosphate concentrations are markedly reduced.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Hyperbaric Oxygen Toxicity Prevention With Succinate.
A. P. Sanders, R. G. Lester, and B. Woodhall (1968)
JAMA 204, 241-246
   Abstract »    PDF »
Protection Against the Toxic Action of Oxygen at High Pressure: Effect of Sodium Succinate on Ehrlich Ascites Cells.
J. W. Bean and B. Thom (1967)
Arch Surg 95, 185-188
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)