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Science 24 December 1965:
Vol. 150. no. 3704, pp. 1735 - 1737
DOI: 10.1126/science.150.3704.1735
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Articles

Lactate Dehydrogenase Isozyme Patterns of Human Platelets and Bovine Lens Fibers

Elliot S. Vesell 1

1 National Institute of Arthritis and Metabolic Diseases, Bethesda, Maryland

Human platelets and bovine lens fibers contain lactate dehydrogenase-3 (LDH-3) as the predominant isozyme but only very faint traces of LDH-5. Since the platelets and lens fibers, like mature human erythrocytes, lack a nucleus, the results strengthen the case for a previously developed association between LDH-5 and the cell nucleus. These three cell types are mainly anaerobic, and therefore their isozyme patterns are incompatible with the theory that anaerobic tissues exhibit predominantly LDH-5 and aerobic tissues mainly LDH-1.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Lactate Dehydrogenase Isozymes: Kinetic Properties at High Enzyme Concentrations.
T. Wuntch, R. F. Chen, and E. S. Vesell (1970)
Science 167, 63-65
   Abstract »    PDF »
Molecular Aspects of Lens Cell Differentiation.
J. Papaconstantinou (1967)
Science 156, 338-346
   Abstract »    PDF »
Human Epidermal Isoenzymes.
A. Ohkawara, J. Halprin, P. Barber, and K. M. Halprin (1967)
Arch Dermatol 95, 412-415
   Abstract »    PDF »
Lactate Dehydrogenase Isozymes of Chick Embryo: Response to Variations of Ambient Oxygen Tension.
S. Lindy and M. Rajasalmi (1966)
Science 153, 1401-1403
   Abstract »    PDF »


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