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Science 3 December 1965:
Vol. 150. no. 3701, pp. 1318 - 1319
DOI: 10.1126/science.150.3701.1318
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Articles

Sleep: Changes in Threshold to Electroconvulsive Shock in Rats after Deprivation of "Paradoxical" Phase

Harry B. Cohen 1 and William C. Dement 1

1 Department of Psychiatry, Stanford University School of Medicine, Palo Alto, California 94304

Rats were deprived of paradoxical (radid eye movement or REM) sleep for a 6-day period but were allowed substantial non-REM (slow wave) sleep. Thresholds for electroconvulsive shock dropped significantly after deprivation in all these animals, but thresholds in control animals treated in a similar manner, but allowed REM sleep exhibited no change. Deprivation seems to heighten neural excitability.


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