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Science 3 December 1965:
Vol. 150. no. 3701, pp. 1296 - 1298
DOI: 10.1126/science.150.3701.1296
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Articles

Adenovirus Multiplication: Genetic Relatedness of Tumorigenic Human Adenovirus Types 7, 12, and 18

S. Lacy 1 and Maurice Green 1

1 Institute for Molecular Virology, Saint Louis University School of Medicine, St. Louis, Missouri

Hybridization measurements among the DNA's of six weakly tumorigenic strains of human adenovirus type 7 reveal that all six strains are very closely related (83- to 110-percent nucleotide sequence homology). The DNA homology between these six type 7 strains and nontumorigenic types 2 and 4 is 32 percent and 52 percent, respectively. The 10- to 20-percent homology between the type 7 DNA's and those of "potent" tumorigenic types 12 and 18 indicates a very low degree of genetic relatedness. These data indicate that, if the carcinogenic potential of adenovirus types 7, 12, and 18 lies in the possession of nucleotide sequences common to these three viruses, these regions represent a small portion of the total genome, approximately one to three viral cistrons.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Transcription of Adenovirus Genes in Productively Infected and in Transformed Cells.
M. Green, J. T. Parsons, M. Pina, K. Fujinaga, H. Caffier, and I. Landgraf-Leurs (1970)
Cold Spring Harb Symp Quant Biol 35, 803-818
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Science. ISSN 0036-8075 (print), 1095-9203 (online)