Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 26 November 1965:
Vol. 150. no. 3700, pp. 1177 - 1178
DOI: 10.1126/science.150.3700.1177
Prev | Table of Contents | Next

Articles

Immunogenicity and Role of Size: Response of Guinea Pigs to Oligotyrosine and Tyrosine Derivatives

Felix Borek 1, Yehudit Stupp 1, and Michael Sela 1

1 Section of Chemical Immunology, Weizmann Institute of Science, Rehovoth, Israel

Guinea pigs injected with 100 micrograms of p-azobenzenearsonate derivatives of hexa-L-tyrosine, tri-L-tyrosine, or N-acetyl-L-tyrosine amide, in complete Freund's adjuvant, developed, after 10 to 19 days, delayed-type hypersensitivity to these substances. This was shown by skin reactions, followed by the formation of circulating antibodies that were detectable by passive cutaneous anaphylaxis. Experiments with p-azobenzenearsonate-hexa-L-tyrosine labeledwith iodine-131 showed that this substance was bound in vitro to proteins of normal guinea pig serum. Binding was similar with the nonantigenic hexa-L-tyrosine and its p-azobenzoate derivative.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Antigenicity: Some Molecular Aspects.
M. Sela (1969)
Science 166, 1365-1374
   PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)