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Science 26 November 1965:
Vol. 150. no. 3700, pp. 1167 - 1168
DOI: 10.1126/science.150.3700.1167
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Articles

Electron Microscopy: Sodium Localization in Normal and Ouabain-Treated Transporting Cells

Gordon I. Kaye 1, Jeanne D. Cole 1, and Anthony Donn 2

1 Division of Surgical Pathology, College of Physicians and Surgeons, Columbia University, New York 10032
2 Institute of Ophthalmology, Presbyterian Hospital, New York

When rabbit corneas are fixed in an osmic acid fixativeto which potassium pyroantimonate has been added, an electron-opaque precipitate of sodiium pyroantimonate is localized along the cellular side of the lateral plasmla membrane of the endothelial cells. This heavy precipitate represents areas of high Na+ concentration and may represent the site of a saturated, high-affinity Na+ carrier. Significantly heavier precipitate occurs at the same site when ouabain is injected into the aqueous humor prior to fixation of the cornea.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Current Thoughts on the Maintenance of Corneal Hydration in Vivo.
J. E. Harris (1967)
Arch Ophthalmol 78, 126-132
   Abstract »    PDF »
Physiological Chemistry of the Eye.
S. J. BONTING (1966)
Arch Ophthalmol 76, 607-622
   PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)