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Science 19 November 1965:
Vol. 150. no. 3699, pp. 1042 - 1044
DOI: 10.1126/science.150.3699.1042
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Phenylketonuria: Limit in Capacity of Pre-Weanling Rats To Oxidize beta-Phenyllactate and Other agr-Hydroxy Acids

Fred B. Goldstein 1

1 Research Department, Letchworth Village, New York State Department of Mental Hygiene, Thiells

In comparison with mature animals, pre-weanling rats have markedly higher and longer lasting serum levels of beta-phenyllactate following the intraperitoneal injection of a moderate dose. A corresponding age-dependent difference in the rate of oxidation of beta-phenyllactate and other agr-hydroxy acids was observed in experiments with homogenates and supernatant fractions of rat kidney.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)