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Science 19 November 1965:
Vol. 150. no. 3699, pp. 1034 - 1035
DOI: 10.1126/science.150.3699.1034
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Articles

Histamine Synthesis and Gastric Secretion after Portacaval Shunt

Josef E. Fischer 1 and Solomon H. Snyder 1

1 National Institute of Mental Health, Bethesda, Maryland

In man there is an increased incidence of peptic ulcer after portacaval shunt. In the rat, 2 months after portacaval anastomosis, there is a generalized increase in the histamine content of the soft tissues, and the increase is most marked in the acid-secreting portion of the stomach. This appears to be secondary to increased activity of the histamine-synthesizing enzyme, histidine decarboxylase. A histidine decarboxylase inhibitor can prevent such hypersecretion of acid in the stomach of these animals.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Acid Secretion Following Portacaval Shunting: Role of Vagus, Gastrin, Intestinal Phase, and Histamine.
P. H. Newman, D. D. Reeder, W. D. Davidson, E. Schneider, J. H. Miller, and J. C. Thompson (1969)
Arch Surg 99, 369-375
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