Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 12 November 1965:
Vol. 150. no. 3698, pp. 905 - 907
DOI: 10.1126/science.150.3698.905
Prev | Table of Contents | Next

Articles

Collagen Defect Induced by Peniciflamine

Marcel E. Nimni 1 and Lucien A. Bavetta 1

1 School of Dentistry, Department of Biochemistry and Nutrition, University of Southern California, Los Angeles

Collagen synthesis, as judged by the accumulation of collagen in a subcutaneous, induced granuloma, was significantly decreased by penicillamine. Penicillamine also caused a marked increase in the amount of soluble collagen in skin and a sharp drop in insoluble material. These findings, which reflect an abnormal pattern of collagen metdbolism, are accompanied by an inhibition of wound-healing and by skin fragility.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Recent developments in the treatment of alcoholic hepatitis.
R. Madhotra and I.T. Gilmore (2003)
QJM 96, 391-400
   Abstract »    Full Text »    PDF »
Recognition, Diagnosis, and Management of Wilson's Disease.
G. J. Brewer (2000)
Experimental Biology and Medicine 223, 39-46
   Abstract »    Full Text »
Treatment of Wilson Disease With Ammonium Tetrathiomolybdate: II. Initial Therapy in 33 Neurologically Affected Patients and Follow-up With Zinc Therapy.
G. J. Brewer, V. Johnson, R. D. Dick, K. J. Kluin, J. K. Fink, and J. A. Brunberg (1996)
Arch Neurol 53, 1017-1025
   Abstract »    PDF »
Bronchiolitis and Bronchitis in Connective Tissue Disease: A Possible Relationship to the Use of Penicillamine.
G. R. Epler, G. L. Snider, E. A. Gaensler, E. S. Cathcart, M. X. FitzGerald, and C. B. Carrington (1979)
JAMA 242, 528-532
   Abstract »    PDF »
Skin Lesions Induced by Penicillamine: Occurrence in a Patient With Hepatolenticular Degeneration (Wilson Disease).
K. E. Greer, F. C. Askew, and D. R. Richardson (1976)
Arch Dermatol 112, 1267-1269
   Abstract »    PDF »
Penicillin G and Wound Healing.
R. Pohl and T. K. Hunt (1970)
Arch Surg 101, 610-611
   Abstract »    PDF »
Copper: Relation to Pencillamine-Iduced Defect in Collagen.
I. A. Jaffe, P. Merriman, and D. Jacobus (1968)
Science 161, 1016-1017
   Abstract »    PDF »
Desmosine Biosynthesis: Nature of Inhibition by D-Penicillamine.
S. R. Pinnell, G. R. Martin, and E. J. Miller (1968)
Science 161, 475-476
   Abstract »    PDF »
Penicillamine for Scleroderma.
D. D. Fulghum and R. Katz (1968)
Arch Dermatol 98, 51-52
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)