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Science 12 November 1965:
Vol. 150. no. 3698, pp. 905 - 907
DOI: 10.1126/science.150.3698.905
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Articles

Collagen Defect Induced by Peniciflamine

Marcel E. Nimni 1 and Lucien A. Bavetta 1

1 School of Dentistry, Department of Biochemistry and Nutrition, University of Southern California, Los Angeles

Collagen synthesis, as judged by the accumulation of collagen in a subcutaneous, induced granuloma, was significantly decreased by penicillamine. Penicillamine also caused a marked increase in the amount of soluble collagen in skin and a sharp drop in insoluble material. These findings, which reflect an abnormal pattern of collagen metdbolism, are accompanied by an inhibition of wound-healing and by skin fragility.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)