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Science 12 November 1965:
Vol. 150. no. 3698, pp. 893 - 899
DOI: 10.1126/science.150.3698.893
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Articles

Bone: Formation by Autoinduction

Marshall R. Urist 1

1 Department of Surgery, University of California Center for Health Sciences, Los Angeles 90024

Wandering histiocytes, foreign body giant cells, and inflammatory connective-tissue cells are stimulated by degradation products of dead matrix to grow in and repopulate the area of an implant of decalcified bone. Histiocytes are more numerous than any other cell form and may transfer collagenolytic activity to the substrate to cause dissolution of the matrix. The process is followed immediately by new-bone formation by autoinduction in which both the inductor cells and the induced cells are derived from ingrowing cells of the host bed. The inductor cell is a descendant of a wandering histiocyte; the induced cell is a fixed histiocyte or perivascular young connective-tissue cell. Differentiation of the osteoprogenitor cell is elicited by local alterations in cell metabolic cycles that are as yet uncharacterized.


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   Abstract »    Full Text »    PDF »
Protein Related to DAN and Cerberus Is a Bone Morphogenetic Protein Antagonist That Participates in Ovarian Paracrine Regulation.
S. Sudo, O. Avsian-Kretchmer, L. S. Wang, and A. J. W. Hsueh (2004)
J. Biol. Chem. 279, 23134-23141
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An Evolutionary and Molecular Analysis of Bmp2 Expression.
K. L. Abrams, J. Xu, C. Nativelle-Serpentini, S. Dabirshahsahebi, and M. B. Rogers (2004)
J. Biol. Chem. 279, 15916-15928
   Abstract »    Full Text »    PDF »
MyoD enhances BMP7-induced osteogenic differentiation of myogenic cell cultures.
M. Komaki, A. Asakura, M. A. Rudnicki, J. Sodek, and S. Cheifetz (2004)
J. Cell Sci. 117, 1457-1468
   Abstract »    Full Text »    PDF »
BIG-3, a Novel WD-40 Repeat Protein, Is Expressed in the Developing Growth Plate and Accelerates Chondrocyte Differentiation in Vitro.
F. Gori and M. B. Demay (2004)
Endocrinology 145, 1050-1054
   Abstract »    Full Text »    PDF »
The Bone Morphogenetic Protein System In Mammalian Reproduction.
S. Shimasaki, R. K. Moore, F. Otsuka, and G. F. Erickson (2004)
Endocr. Rev. 25, 72-101
   Abstract »    Full Text »    PDF »
Successful Treatment of an Adynamic Bone Disorder with Bone Morphogenetic Protein-7 in a Renal Ablation Model.
R. J. Lund, M. R. Davies, A. J. Brown, and K. A. Hruska (2004)
J. Am. Soc. Nephrol. 15, 359-369
   Abstract »    Full Text »    PDF »
Management of Posttraumatic Segmental Bone Defects.
T. A. DeCoster, R. J. Gehlert, E. A. Mikola, and M. A. Pirela-Cruz (2004)
J. Am. Acad. Ortho. Surg. 12, 28-38
   Abstract »    Full Text »    PDF »
Retroviral Delivery of Noggin Inhibits the Formation of Heterotopic Ossification Induced by BMP-4, Demineralized Bone Matrix, and Trauma in an Animal Model.
D. Hannallah, H. Peng, B. Young, A. Usas, B. Gearhart, and J. Huard (2004)
J. Bone Joint Surg. Am. 86, 80-91
   Abstract »    Full Text »    PDF »
Brief Bone Morphogenetic Protein 2 Treatment of Glucocorticoid-inhibited MC3T3-E1 Osteoblasts Rescues Commitment-associated Cell Cycle and Mineralization without Alteration of Runx2.
C. A. Luppen, N. Leclerc, T. Noh, A. Barski, A. Khokhar, A. L. Boskey, E. Smith, and B. Frenkel (2003)
J. Biol. Chem. 278, 44995-45003
   Abstract »    Full Text »    PDF »
Cartilage morphogenetic proteins: role in joint development, homoeostasis, and regeneration.
A H Reddi (2003)
Ann Rheum Dis 62, ii73-78
   Abstract »    Full Text »    PDF »
Sulfated Polysaccharides Enhance the Biological Activities of Bone Morphogenetic Proteins.
T. Takada, T. Katagiri, M. Ifuku, N. Morimura, M. Kobayashi, K. Hasegawa, A. Ogamo, and R. Kamijo (2003)
J. Biol. Chem. 278, 43229-43235
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BMP-2-induced Runx2 Expression Is Mediated by Dlx5, and TGF-{beta}1 Opposes the BMP-2-induced Osteoblast Differentiation by Suppression of Dlx5 Expression.
M.-H. Lee, Y.-J. Kim, H.-J. Kim, H.-D. Park, A.-R. Kang, H.-M. Kyung, J.-H. Sung, J. M. Wozney, H.-J. Kim, and H.-M. Ryoo (2003)
J. Biol. Chem. 278, 34387-34394
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BMPER, a Novel Endothelial Cell Precursor-Derived Protein, Antagonizes Bone Morphogenetic Protein Signaling and Endothelial Cell Differentiation.
M. Moser, O. Binder, Y. Wu, J. Aitsebaomo, R. Ren, C. Bode, V. L. Bautch, F. L. Conlon, and C. Patterson (2003)
Mol. Cell. Biol. 23, 5664-5679
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Osteogenic Activity of the Fourteen Types of Human Bone Morphogenetic Proteins (BMPs).
H. Cheng, W. Jiang, F. M. Phillips, R. C. Haydon, Y. Peng, L. Zhou, H. H. Luu, N. An, B. Breyer, P. Vanichakarn, et al. (2003)
J. Bone Joint Surg. Am. 85, 1544-1552
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What's New in Spine Surgery.
J. E. Zigler, P. A. Anderson, S. D. Boden, K. H Bridwell, and A. R. Vaccaro (2003)
J. Bone Joint Surg. Am. 85, 1626-1636
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Marshall R. Urist: A Renaissance Scientist and Orthopaedic Surgeon.
A. H. Reddi (2003)
J. Bone Joint Surg. Am. 85, 3-7
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Signal Transduction of Bone Morphogenetic Proteins in Osteoblast Differentiation.
P. t. Dijke, J. Fu, P. Schaap, and B. A.J. Roelen (2003)
J. Bone Joint Surg. Am. 85, 34-38
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Structural Basis of BMP Signaling Inhibition by Noggin, a Novel Twelve-Membered Cystine Knot Protein.
J. Groppe, J. Greenwald, E. Wiater, J. Rodriguez-Leon, A. N. Economides, W. Kwiatkowski, K. Baban, M. Affolter, W. W. Vale, J. C. Belmonte, et al. (2003)
J. Bone Joint Surg. Am. 85, 52-58
   Abstract »    Full Text »    PDF »


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