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Science 5 November 1965:
Vol. 150. no. 3697, pp. 760 - 763
DOI: 10.1126/science.150.3697.760
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Articles

Recombination in Bacteriophage T4: a Mechanism

E. Simon 1

1 Department of Biological Sciences, Purdue University, Lafayette, Indiana

Genetic recombination between rIl mutants of T4 bacteriophage grown in Escherichia coli can occur under conditions where DNA synthesis is strongly inhibited by 5-fluorodeoxyuridine. The small amount of DNA synthesized under these conditions cannot account for the observed frequency of recombinants. The major mechanism of recombination in this system is a process of breakage and rejoining.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)