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Science 5 November 1965:
Vol. 150. no. 3697, pp. 752 - 754
DOI: 10.1126/science.150.3697.752
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Articles

Uptake as a Determinant of Methotrexate Response in Mouse Leukemias

David Kessel 1, Thomas C. Hall 1, DeWayne Roberts 1, and Isidore Wodjnsky 2

1 Children's Cancer Research Foundation, Boston, Massachusetts
2 Arthur D. Little, Inc., Cambridge, Massachusetts

Methotrexate-promoted survival of mice bearing different transplantable leukemias was compared with uptake of the drug by leukemia cells in vitro. A high degree of correlation (r2 = 0.88) showed that uptake may be a major determinant of the antitumor activity of methotrexate against transplantable mouse leukemias.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Single Amino Acid Difference within the Folate Transporter Encoded by the Murine RFC-1 Gene Selectively Alters its Interaction with Folate Analogues. IMPLICATIONS FOR INTRINSIC ANTIFOLATE RESISTANCE AND DIRECTIONAL ORIENTATION OF THE TRANSPORTER WITHIN THE PLASMA MEMBRANE OF TUMOR CELLS.
K. Roy, B. Tolner, J. H. Chiao, and F. M. Sirotnak (1998)
J. Biol. Chem. 273, 2526-2531
   Abstract »    Full Text »    PDF »
Isolation of Human cDNAs That Restore Methotrexate Sensitivity and Reduced Folate Carrier Activity in Methotrexate Transport-defective Chinese Hamster Ovary Cells.
S. C. Wong, S. A. Proefke, A. Bhushan, and L. H. Matherly (1995)
J. Biol. Chem. 270, 17468-17475
   Abstract »    Full Text »    PDF »
Growth Rate Patterns of Solid Tumors and Their Relation to Responsiveness to Therapy: An Analytical Review.
S. E. SHACKNEY, G. W. McCORMACK, and G. J. CUCHURAL Jr. (1978)
Ann Intern Med 89, 107-121
   Abstract »    PDF »
Transport and Phosphorylation as Factors in the Antitumor Action of Cytosine Arabinoside.
D. Kessel, T. C. Hall, and I. Wodinsky (1967)
Science 156, 1240-1241
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)