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Science 8 October 1965:
Vol. 150. no. 3693, pp. 226 - 228
DOI: 10.1126/science.150.3693.226
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Articles

Hemolysin of Mycoplasma pneumoniae: Tentative Identification as a Peroxide

Norman L. Somerson 1, Barbara E. Walls 1, and Robert M. Chanock 1

1 National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014

Mycoplasma pneumoniae produces a soluble hemolysin active against guinea pig erythrocytes. This hemolysin appears to be a peroxide, since catalase or peroxidase inhibits its activity. The action of catalase and peroxidase is specific, since heating the enzymes abolishes their effect on the hemolysin. In addition, 3-amino- 1,2,4-triazole, a potent inhibitor of catalase, reverses the inhibitory effect of the enzyme. The hemolysin of M. laidlawii is also a peroxide. The hemolysins of M. pneumoniae and M. laidlawii seem unique for microbial organisms since the bacterial hemolysins which have been described have been protein or lipid in nature.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)