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Science 17 September 1965:
Vol. 149. no. 3690, pp. 1390 - 1391
DOI: 10.1126/science.149.3690.1390
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Articles

Prostaglandin: Release from the Rat Phrenic Nerve-Diaphragm Preparation

P. W. Ramwell 1, Jane E. Shaw 1, and J. Kucharski 1

1 Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts

Release of a substance that stimulates smooth muscle was detected from a phrenic nerve-diaphragm preparation from the rat upon direct and indirect stimulation. On thin-layer chromatography most of the active material behaved as a mixture of prostaglandins. The effect of electrical stimulation was mimicked by catecholamines but not by acetylcholine or eserine. The effect of nerve stimulation was not antagonized by d-tubocurarine.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Prostaglandins: Members of a New Hormonal System: These physiologically very potent compounds of ubiquitous occurrence are formed from essential fatty acids.
S. Bergstrom (1967)
Science 157, 382-391
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