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Science 10 September 1965:
Vol. 149. no. 3689, pp. 1255 - 1258
DOI: 10.1126/science.149.3689.1255
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Articles

Anesthesia of Artemia Larvae: Method for Quantitative Study

Arthur B. Robinson 1, Kenneth F. Manly 1, Michael P. Anthony 1, John F. Catchpool 1, and Linus Pauling 1

1 Gates and Crellin Laboratories of Chemistry, California Institute of Technology, Pasadena

Potency of anesthetics is quantitatively measured with laboratory-hatched larvae of the brine shrimp Artemia salina. Statistical fluctuations are minimized in that 100,000 animals are used to determine a single median anesthetic dose value. The technique was developed to study molecular mechanisms of general anesthesia.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)