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Science 3 September 1965:
Vol. 149. no. 3688, pp. 1106 - 1107
DOI: 10.1126/science.149.3688.1106
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Articles

Induction in vitro of Antibodies to Phage T2: Antigens in the RNA Extract Employed

H. P. Friedman 1, A. B. Stavitsky 1, and J. M. Solomon 1

1 Western Reserve University School of Medicine, Department of Microbiology, Cleveland, Ohio 44106

Cells from rat peritoneal exudate incubated in vitro with phage T2 yield RNA which induces cultures of rat lymph nodes to form antibodies. Complement fixation reveals T2 head, tail, and internal protein antigens in the RNA. Inoculating the RNA into mice that had previously been stimulated primarily with whole phage T2 results in a secondary response of neutralizing antibody.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mediation of Immunity to Tumor Isografts in Mice by Heterologous Ribonucleic Acid.
K. P. Ramming and Y. H. Pilch (1970)
Science 168, 492-493
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Macrophage Ribonucleoprotein: Nature of the Antigenic Fragment.
A. A. Gottlieb (1969)
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A Requirement for Two Cell Types for Antibody Formation in vitro.
D. E. Mosier (1967)
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Death in Embryonic Systems.
J. W. Saunders Jr. (1966)
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Immunization of Normal Mouse Spleen Cell Suspensions in vitro.
R. I. Mishell and R. W. Dutton (1966)
Science 153, 1004-1006
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Antigen-RNA Complexes.
S. M. Sabesin (1966)
Science 153, 659
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Biosynthesis of Gamma Globulin: Studies in a Cell-Free System.
K. H. Stenzel and A. L. Rubin (1966)
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Antibody Synthesis Initiated in vitro by Paired Explants of Spleen and Thymus.
G. C. Saunders and D. W. King (1966)
Science 151, 1390-1391
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Primary-Type Antibody Response in vitro.
T.-W. Tao and J. W. Uhr (1966)
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Science. ISSN 0036-8075 (print), 1095-9203 (online)