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Science 3 September 1965:
Vol. 149. no. 3688, pp. 1100 - 1101
DOI: 10.1126/science.149.3688.1100
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Articles

Nucleoside Incorporation into Strain L Cells: Inhibition by Pleuropneumonia-Like Organisms

Roland M. Nardone 1, Jean Todd 1, Paula Gonzalez 1, and Edwin V. Gaffney 1

1 Department of Biology, Catholic University of America, Washington, D.C.

Contamination of Strain L cell cultures by pleuropneumonia-like organismtis (PPLO) resulted in a complete inhibition of the incorporation of tritiated thymnidine and uridine. Contanminated cultures were characterized by a concentration of PPLO along the margins of the cells and in the intercellular-spaces of the cultures. Autoracliograins of PPLO-contaminated cultures were characterized by exposed silver grains over the margins of the cells. Kanamnycin was efjective in the elimination of PPLO and the restoration of nucleoside incorporation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Virus-Like Particles in Established Murine Cell Lines: Electron-Microscopic Observations.
D. A. Kindig and W. H. Kirsten (1967)
Science 155, 1543-1545
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Chromosome Changes Induced by Infections in Tissues of Rhynchosciara angelae.
C. Pavan and R. Basile (1966)
Science 151, 1556-1558
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Science. ISSN 0036-8075 (print), 1095-9203 (online)