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Science 3 September 1965:
Vol. 149. no. 3688, pp. 1093 - 1095
DOI: 10.1126/science.149.3688.1093
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Articles

Turnover of Ribosomal RNA in Rat Liver

John N. Loeb 1, R. Rodney Howell 1, and Gordon M. Tomkins 1

1 National Institute of Arthritis and Metabolic Diseases, Bethesda, Maryland 20014

After a single injection of radioactive orotic acid and a "chase" of nonradioactive precursor, the specific activity of ribosomal RNA in rat liver decreases logarithmically at a rate corresponding to a half-life of about S days. The possible significance of this result is discussed with regard to control of protein synthesis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Differential breakdown of phylogenetically diverse ribosomal RNA's inserted via liposomes into mammalian cells.
D Lavelle, M. Ostro, and D Giacomoni (1982)
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Science. ISSN 0036-8075 (print), 1095-9203 (online)