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Science 27 August 1965:
Vol. 149. no. 3687, pp. 991 - 993
DOI: 10.1126/science.149.3687.991
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Articles

Primary Immune Reactions in Organ Cultures

Amiela Globerson 1 and Robert Auerbach 1

1 Department of Zoology University of Wisconsin, Madison

Primary immune reactions were initiated and maintained in vitro. Spleen explants from mice treated with either phytohemagglutinin or adjuvant were stimulated to form hemagglutinins and hemolysins, whereas no treatment of spleen donors was necessary to invoke a "graft-versus-host" response which led to specific splenomegly.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Immunization of Normal Mouse Spleen Cell Suspensions in vitro.
R. I. Mishell and R. W. Dutton (1966)
Science 153, 1004-1006
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Antibody Synthesis Initiated in vitro by Paired Explants of Spleen and Thymus.
G. C. Saunders and D. W. King (1966)
Science 151, 1390-1391
   Abstract »    PDF »
Primary-Type Antibody Response in vitro.
T.-W. Tao and J. W. Uhr (1966)
Science 151, 1096-1098
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)