Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 13 August 1965:
Vol. 149. no. 3685, pp. 751 - 752
DOI: 10.1126/science.149.3685.751
Prev | Table of Contents | Next

Articles

Immunization against Rauscher Mouse Leukemia with Tissue Culture Material

Georges Barski 1 and Jung Koo Youn 1

1 Institut Gustave Roussy, Villejuif (Seine), France, and Sloan-Kettering Institute for Cancer Research, New York

Long-term monolayer cultures of mouse thymus and spleen cells, chronically infected with Rauscher virus, showed only a very attenuated leukemia-producing capacity. Material from these cultures prepared from normal BALB/ c mouse tissue was used to immunize isologous mice against subsequent challenge with fully active Rauscher virus. The centrifuged supernatant of the culture had some immunizing properties. However, the most efficient protectionwas obtained when cell suspensions from these cultures were used in the form of a series of three intraperitoneal and intramuscular injections and onebooster injection.

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)