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Science 6 August 1965:
Vol. 149. no. 3684, pp. 650 - 651
DOI: 10.1126/science.149.3684.650
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Articles

Renin Production by Organ Cultures of Renal Cortex

Abel L. Robertson Jr. 1, Robert R. Smeby 1, F. Merlin Bumpus 1, and Irvine H. Page 1

1 Research Division, Cleveland Clinic Foundation, Cleveland, Ohio 44106

Diploid cells of the human and canine renal cortex can be isolated by newly developed techniques for organ culture. Some of these cells have abundant Bowie's positive granules. Bioassays for renin activity have shown that these granular cells can synthesize considerable amounts of renin in vitro. These investigations provide a model for studying the production of renin at cellular level.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Physiology of Renin.
J. H. Stein and T. F. Ferris (1973)
Arch Intern Med 131, 860-872
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Science. ISSN 0036-8075 (print), 1095-9203 (online)