Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 30 July 1965:
Vol. 149. no. 3683, pp. 548 - 550
DOI: 10.1126/science.149.3683.548
Prev | Table of Contents | Next

Articles

Adaptive Enzyme Synthesis: Its Inhibition as a Possible Analogue of Immunological Tolerance

D. W. van bekkum 1 and H. T. M. Nieuwerkerk 1

1 Radiobiological Institute, Organization for Applied Scientific Research, Rijswijk (Z.H.), Netherlands

Substrate induction of tryptophan pyrrolase in the liver of rats is inhibited by prior treatment of very young rats with tryptophan. This inhibition seems analogous to immunological tolerance, which can be produced by prior treatment with the antigen. The findings prowide support for an analogy between mechanisms of adaptive enzyme synthesis and those involved in adaptive immunity.

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)