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Science 30 July 1965:
Vol. 149. no. 3683, pp. 542 - 543
DOI: 10.1126/science.149.3683.542
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Articles

Circadian Rhythm in Pineal Serotonin: Effect of Monoamine Oxidase Inhibition and Reserpine

Solomon H. Snyder 1 and Julius Axelrod 1

1 Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014

The pineal gland of the rat shows a circadian rhythm in its serotonin content, the amount of serotonin decreasing at night. This decrease can be prevented by inhibiting the action of monoamine oxidase. Reserpine abolishes the circadian rhythm in pineal serotonin in the same manner as does interruption of the sympathetic nervous connections of the central nervous system and the pineal gland. These observations suggest that circadian changes in release and binding of serotonin may occur in the pineal gland, and that a central mechanism in which monoamines participate may control the circadian pineal-serotonin rhythm.


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