Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 23 July 1965:
Vol. 149. no. 3682, pp. 432 - 435
DOI: 10.1126/science.149.3682.432
Prev | Table of Contents | Next

Articles

Adult Thymectomy: Effect on Recovery from Immunologic Depression in Mice

Anthony P. Monaco 1, Mary L. Wood 1, and Paul S. Russell 1

1 Department of Surgery, Massachusetts General Hospital, Boston

A/Jax mice treated for I week with rabbit antiserum to A/Jax lymphocytes showed peripheral lymphopenia and tissue lymphocyte depletion which persisted for 4 weeks after initiation of serum treatment. During this time, such animals showed depression of the humoral antibody response and inability to reject skin allografts. After 4 weeks, mice recovered from effects of serum treatment. Normal blood and tissue lymphocyte levels returned, and immunologic competence was restored. Thymectomy of A/Jax mice (8 to 10 weeks old) prior to serum treatment resulted in peripheral and tissue lymphopenia and depression of antibody formation, which persisted twice as long as that shown by animals given serum alone. Similarly, skin allografts survive two to four times longer in serum-treated thymectomized mice, and, in some cases persisted over 100 days in perfect condition.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Splenectomy and the Thymic Involution of Increasing Age.
J. A. Meyer and J. D. Meyer (1978)
Arch Surg 113, 972-975
   Abstract »    PDF »
Long-term survival of skin allografts in mice treated with fractionated total lymphoid irradiation.
S Slavin, S Strober, Z Fuks, and H. Kaplan (1976)
Science 193, 1252-1254
   Abstract »    PDF »
Antilymphocyte Serum or Antithymus Serum.
H. Nagaya (1970)
Arch Intern Med 125, 499-502
   Abstract »    PDF »
Protective Effect of Antilymphocyte Serum on Mice Infected with Plasmodium berghei.
J. N. Sheagren and A. P. Monaco (1969)
Science 164, 1423-1425
   Abstract »    PDF »
Skin Allograft Survival in Calves: Influence of Thymectomy and Extracorporeal Irradiation of Blood.
A. D. Chanana, E. P. Cronkite, D. D. Joel, and L. M. Schiffer (1969)
Arch Surg 98, 803-805
   Abstract »    PDF »
Antiserum to Lymphocytes: Interactions with Chemical Immunosuppressants.
R. L. Simmons, A. J. Ozerkis, and R. J. Hoehn (1968)
Science 160, 1127-1130
   Abstract »    PDF »
Mixed Lymphocyte Reaction: An in vitro Test for Antilymphocytic Serum Activity.
M. R. Schwarz, R. W. Tyler, and N. B. Everett (1968)
Science 160, 1014-1017
   Abstract »    PDF »
Antiserum to Lymphocytes: Prolonged Survival of Canine Renal Allografts.
A. P. Monaco, W. M. Abbott, H. B. Othersen, R. L. Simmons, M. L. Wood, M. H. Flax, and P. S. Russell (1966)
Science 153, 1264-1267
   Abstract »    PDF »
Tissue Transplantation: Scope and Prospect.
R. E. Billingham (1966)
Science 153, 266-270
   PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)