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Science 9 July 1965:
Vol. 149. no. 3680, pp. 182 - 184
DOI: 10.1126/science.149.3680.182
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Articles

Actinomycin D Inhibition of Vitamin D Action

J. Elwood Zull 1, E. Czarnowska-Misztal 1, and Hector F. DeLuca 1

1 Department of Biochemistry, College of Agriculture, University of Wisconsin, Madison, 53706

Injection of actinomycin D into rats completely prevents both the rise in serum calcium normally induced by vitamin D and the increased transport of calcium by everted intestinal sacs. Injection of excess parathyroid hormone did not alter this result; this eliminates the possibility that the inhibition of vitamin action was due to blocked hormone synthesis. As a result of these findings, a hypothesis concerning the mechanism of action of vitamin D is presented.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Vitamin D: A Cholecalciferol Metabolite Highly Active in Promoting Intestinal Calcium Transport.
J. F. Myrtle and A. W. Norman (1971)
Science 171, 79-82
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Intestinal Calcium Absorption: Nature of Defect in Chronic Renal Disease.
L. V. Avioli, S. Scott, S. W. Lee, and H. F. D. Luca (1969)
Science 166, 1154-1156
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The Nature of Vitamin D Resistance of Patients With Chronic Renal Disease.
L. V. Avioli, S. J. Birge, and E. Slatopolsky (1969)
Arch Intern Med 124, 451-454
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25-Hydroxycholecalciferol: Direct Effect on Calcium Transport.
E. B. Olson and H. F. Deluca (1969)
Science 165, 405-407
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Actinomycin D Effect on Amino Acid Absorption from Rat Jejunal Loops.
C. Yamada, A. J. Clark, and M. E. Swendseid (1967)
Science 158, 129-130
   Abstract »    PDF »
Basic Science Review : Calcium and Phosphorus Current Concepts of Metabolism.
C. C. Roy and D. O'Brien (1967)
Clinical Pediatrics 6, 19-28
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Vitamin D3-Induced Calcium-Binding Protein in Chick Intestinal Mucosa.
R. H. Wasserman and A. N. Taylor (1966)
Science 152, 791-793
   Abstract »    PDF »


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