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Science 2 July 1965:
Vol. 149. no. 3679, pp. 84 - 85
DOI: 10.1126/science.149.3679.84
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Articles

Nonspecific Binding of Complement by Digestion Fragments from Antiviral Gamma Globulin

Natalie E. Cremer 1, John L. Riggs 1, Edwin H. Lennette 1, and Florence W. Jensen 1

1 Viral and Rickettsial Disease Laboratory, California State Department of Public Health, Berkeley

The nonspecificity of rabbit ggr-globulin (antibody) to western equine encephalitis virus and the non-specificity of normal rabbit ggr-globulin in complement-fixation tests with anti-gens prepared from chick-embryo cells infected with this virus and normal chick-embryo cells resided primarily in Porter's fragment III. Addition of complement to fragment III from the anti-body globulin, followed by inactivation of the added complement, abolished the complement-fixing ability of fragment III with both specific and nonspecific antigens. Similar treatment of the undigested antibody abolished its complement-fixing ability with nonspecific antigen only.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)