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Science 25 June 1965:
Vol. 148. no. 3678, pp. 1746 - 1747
DOI: 10.1126/science.148.3678.1746
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Articles

Radiation Resistance in Lipovirus-Altered Human Cells

John B. Little 1 and R. Shihman Chang 1

1 Departments of Physiology and Microbiology, Harvard School of Public Health, Boston, Massachusetts

Human cells altered by infection with the "lipovirus," a transmissible cytopathic agent, are highly resistant to ionizing radiation. Whereas about 500 roentgens will inhibit cell multiplication in normal cells, more than 500,000 roentgens are required to produce a similar effect in the altered cells. This gross change in cellular radiosensitivity may provide a useful system for studying in vitro the mechanisms of inhibition of cell division by radiation.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)