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Science 25 June 1965:
Vol. 148. no. 3678, pp. 1737 - 1739
DOI: 10.1126/science.148.3678.1737
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Articles

Thyroid and Parathyroid Roles in Hypercalcemia: Evidence for a Thyrocalcitonin-Releasing Factor

Ruben F. Gittes 1 and George L. Irvin 1

1 Surgery Branch, National Cancer Institute, Bethesda, Maryland 20014

Extirpation of either the parathyroids or the thyroid in rats acutely impaired their ability to counteract hypercalcemia induced by exogenous parathormone. Thyroidectomy had the greater effect, and in rats subjected to both parathyroidectomy and thyroidectomy the calcium-lowering mechanism was not further impaired, which suggests that the parathyroids secrete a humoral factor that releases calcium-lowering thyrocalcitonin from the thyroid. This hypothesis reconciles previous conflicting reports.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Thyrocalcitonin: Its Role in Calcium Homeostasis.
M. A. Aliapoulios, D. S. Bernstein, and M. C. Balodimos (1969)
Arch Intern Med 123, 88-94
   Abstract »    PDF »
Thyrotropin Hormone Deficiency: With a Peripheral Neuropathy.
J. D. Grabow and S. M. Chou (1968)
Arch Neurol 19, 284-291
   Abstract »    PDF »
Basic Science Review : Calcium and Phosphorus Current Concepts of Metabolism.
C. C. Roy and D. O'Brien (1967)
Clinical Pediatrics 6, 19-28
   PDF »
Thyrocalcitonin.
P. L. MUNSON (1966)
Ann Intern Med 64, 1353-1357
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)