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Science 25 June 1965:
Vol. 148. no. 3678, pp. 1731 - 1733
DOI: 10.1126/science.148.3678.1731
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Articles

Reversion in Hamster Cells Transformed by Rous Sarcoma Virus

Ian Macpherson 1

1 Medical Research Council Unit for Experimental Virus Research, Institute of Virology, University of Glasgow, Glasgow, Scotland

Hamster cells of the BHK-21 line are transformable by Rous sarcoma virus (Schmidt-Ruppin strain). The transformed cells form colonies in agar suspension culture, grow on glass in disarray, and initiate tumors in hamsters and chickens, but extracts do not induce tumors in chickens. Chickens bearing tumors develop neutralizing antibody against the virus. Transformed cell clones give rise to "revertants" which form colonies on glass with cells oriented parallel to each other like the original uninfected cells. These revertants do not grow in agar or initiate chicken tumors, and they regain the original low transplantability of untransformed cells in hamsters.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Synthesis, Structure and Function of Avian Sarcoma Virus-specific DNA in Permissive and Nonpermissive Cells.
H. E. Varmus, R. V. Guntaka, C. T. Deng, and J. M. Bishop (1974)
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Activation and Repression of Virus Expression in Mammalian Cells Infected by Rous Sarcoma Virus.
D. Boettiger (1974)
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Reversion of Murine Sarcoma Virus Transformed Mouse Cells: Variants without a Rescuable Sarcoma Virus.
P. J. Fischinger, S. Nomura, P. T. Peebles, D. K. Haapala, and R. H. Bassin (1972)
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Molecular Virology and Cancer.
C. R. Goodheart (1965)
JAMA 194, 48-53
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