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Science 11 June 1965:
Vol. 148. no. 3676, pp. 1477 - 1479
DOI: 10.1126/science.148.3676.1477
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Articles

Particles Resembling Papova Viruses in Human Cerebral Demyelinating Disease

Gabriele M. Zu Rhein 1 and Shi-Ming Chou 1

1 Departments of Pathology and Neurology, University of Wisconsin Medical School, Madison

Degenerated brain tissue obtained from a deceased patient who had progressive multifocal leukoencephalopathy had been fixed in formalin prior to processing for electron microscopy. In ultrathin sections virus-like particles resembling papova virions were frequently observed in glial nuclei. Correlation with light-microscopy findings suggests that demyelination resulted from the cytocidal effect of the virus on oligodendroglia.


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