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Science 4 June 1965:
Vol. 148. no. 3675, pp. 1333 - 1335
DOI: 10.1126/science.148.3675.1333
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Articles

Immunologic Tolerance in Thymectomized, Irradiated Rats Grafted with Thymus from Tolerant Donors

Katarina Isakovicacute 1, Stanley B. Smith 1, and Byron H. Waksman 1

1 Departments of Microbiology, Faculty of Pharmacy, Belgrade University, Belgrade, Yugoslavia, and Yale University, New Haven

Lewis rats, thymectomized at 5 weeks of age and irradiated at 8 weeks, received grafts of adult thymus and marrow, one or both grafts being derived from donors tolerant to bovine ggr-globulin. Challenge 3 or 6 weeks after grafting showed that delayed sensitization could not be induced in animals which received a tolerant thymus or tolerant thymus and marrow, though sensitization to a heterologous antigen (chicken ovalbumin) occurred normally. Arthus reactivity was regained slowly in animals receiving normal thymus and marrow and, to an equal extent, in those receiving grafts from tolerant donors.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Immunological Competence: Alteration by Whole Body X-Irradiation and Shielding of Selected Lymphoid Tissues.
J. Miller (1966)
Science 151, 1395-1397
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Science. ISSN 0036-8075 (print), 1095-9203 (online)