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Science 28 May 1965:
Vol. 148. no. 3674, pp. 1240 - 1241
DOI: 10.1126/science.148.3674.1240
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Articles

Quinine-Resistant Plasmodium berghei in Mice

Paul E. Thompson 1, Anita Bayles 1, Bronislawa Olszewski 1, and J. Allan Waitz 1

1 Research Division, Parke, Davis & Company, Ann Arbor, Michigan

During induction of chloroquine resistance, Plasmodium berghei developed resistance to quinine administered in doses near the maximum amounts tolerated by mice. Resistant parasites did not form malarial pigment. Normal sensitivity to both quinine and chloroquine returned and pigment formation resumed during serial passage of the parasites through untreated mice.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)