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Science 30 April 1965:
Vol. 148. no. 3670, pp. 640 - 642
DOI: 10.1126/science.148.3670.640
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Articles

Linkage in Control of Allotypic Specificities on Two Different ggrG-Immunoglobulins

Rose Lieberman 1, Sheldon Dray 1, and Michael Potter 1

1 Laboratory of Clinical Investigations and Laboratory of Immunology, National Institute of Allergy and Infectious Diseases and Laboratory of Biology, National Cancer Institute, Bethesda, Maryland

Allotypic specificities were identified on two different myeloma proteins and the corresponding normal ggrG-immunoglobulins of BALB/c mice. When the sera of F2 progeny from a cross between BALB/c mice having the a1 allotype and AL mice having the a4 allotype were tested for these specificities, it was found that the two allotypic specificities of the BALB/c mice were either both present (87 mice) or both absent (36 mice), an indication of linkage in their genetic control.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Chromosome Region for Immunoglobulin Heavy Chains in the Mouse: Allelic Electrophoretic Mobility Differences and Allotype Suppression.
L. A. Herzenberg, J. D. Minna, and L. A. Herzenberg (1967)
Cold Spring Harb Symp Quant Biol 32, 181-186
   Abstract »    PDF »
Genetic Studies of Immunoglobulins in Mice.
M. Potter and R. Lieberman (1967)
Cold Spring Harb Symp Quant Biol 32, 187-202
   Abstract »    PDF »
Biosynthesis of the Carbohydrate Portion of Immunoglobulin Chains: Possible Relation to Secretion.
F. Melchers and P. M. Knopf (1967)
Cold Spring Harb Symp Quant Biol 32, 255-262
   Abstract »    PDF »
Polymorphism of Heavy-Chain Genes in Immunoglobulins of Wild Mice.
R. Lieberman and M. Potter (1966)
Science 154, 535-537
   Abstract »    PDF »
Macroglobulin-Producing Plasma-Cell Tumor in Mice: Identification of a New Light Chain.
K. R. Mcintimif, R. M. Asofsky, M. Potter, and E. L. Kuff (1965)
Science 150, 361-363
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)