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Science 30 April 1965:
Vol. 148. no. 3670, pp. 632 - 634
DOI: 10.1126/science.148.3670.632
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Articles

Enzymatic Synthesis of Tri- and Tetranucleotides of Defined Sequence

R. E. Thach 1 and Paul Doty 1

1 Department of Chemistry, Harvard University, Cambridge, Massachusetts

Conditions have been found under which polynucleotide phosphorylase adds only a few nucleotide residues to the 3' end of a dinucleotide primer. Pure tri- and tetranucleotides can be isolated from reaction mixtures in high yield.


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