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Science 16 April 1965:
Vol. 148. no. 3668, pp. 380 - 381
DOI: 10.1126/science.148.3668.380
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Articles

Peptides Attached to Thrombin: Their Influence on Proteolysis

Ricardo H. Landaburu 1, Osvaldo Abdala 1, and Jorge Morrone 1

1 National University of Córdoba Medical School, Institute of Pharmacology, Córdoba, Argentina

During the activation of prothrombin at least two peptides are split off the molecule. These peptides become attached to thrombin, changing its proteolytic activity. Depending on the peptide adsorbed the endopeptidase activity of thrombin increases or diminishes. Acidification of thrombin by acetylation of amino groups uncovers the influence of peptides on the properties of thrombin.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)