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Science 9 April 1965:
Vol. 148. no. 3667, pp. 242 - 244
DOI: 10.1126/science.148.3667.242
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Articles

Histone Regulation of Lactic Dehydrogenase in Embryonic Chick Brain Tissue

B. C. Goodwin 1 and I. W. Sizer 1

1 Department of Biology, Massachusetts Institute of Technology, Cambridge 02139

Histone, when added at low concentrations to cultures of embryonic chick brain tissue, causes an inductive response in lactic dehydrogenase activity, whereas at higher concentrations of histone the response is repressive. This control is shown to operate by altering protein synthesis. Thus, histones exercise a primary regulatory function in the chick. Unlike lactic dehydrogenase, acetylcholine esterase is stable in this system and is not affected by histones or inhibitors of protein synthesis.


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