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Science 2 April 1965:
Vol. 148. no. 3666, pp. 97 - 98
DOI: 10.1126/science.148.3666.97
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Articles

Coxsackie A9 Virus: Mutation from Drug Dependence to Drug Independence

Hans J. Eggers 1 and Igor Tamm 1

1 Rockefeller Institute, New York, New York 10021

During the multiplication of Coxsackie A9 virus dependent on 2 - (agr - hydroxybenzyl) - benzimidazole there arise some drug-independent virus particles, which are either drug-resistant or drug-sensitive. We studied the properties of such revertant particles under conditions which did not favor the selection of resistant over sensitive virus particles. These particles exhibited a wide range of responses to 2-(agr-hydroxybenzyl)-benzimidazole, from high sensitivity to high resistance. Subclones showed the same degree of sensitivity or resistance as the respective parent clones.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
RNA virus error catastrophe: Direct molecular test by using ribavirin.
S. Crotty, C. E. Cameron, and R. Andino (2001)
PNAS 98, 6895-6900
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Science. ISSN 0036-8075 (print), 1095-9203 (online)