Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 26 March 1965:
Vol. 147. no. 3665, pp. 1588 - 1590
DOI: 10.1126/science.147.3665.1588
Prev | Table of Contents | Next

Articles

Erythropoiesis in the Chick Embryo: The Role of Endoderm

Fred H. Wilt 1

1 Department of Zoology, University of California, Berkeley

The endoderm can be separated from the ectomesoderm of the area vasculosa of the early chick embryo. The development of the separated germ layers in organ cultures shows that the endoderm is necessary for the normal formation of blood islands by mesodermal cells. In the absence of endoderm the mesodermal cells undergo erythropoiesis in dispersed groups of cells but do not form endothelium.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Ventral embryonic tissues and Hedgehog proteins induce early AGM hematopoietic stem cell development.
M. Peeters, K. Ottersbach, K. Bollerot, C. Orelio, M. de Bruijn, M. Wijgerde, and E. Dzierzak (2009)
Development 136, 2613-2621
   Abstract »    Full Text »    PDF »
Brachyury is required for elongation and vasculogenesis in the murine allantois.
K. E. Inman and K. M. Downs (2006)
Development 133, 2947-2959
   Abstract »    Full Text »    PDF »
TGF{beta} inhibition of yolk-sac-like differentiation of human embryonic stem-cell-derived embryoid bodies illustrates differences between early mouse and human development.
E. Poon, F. Clermont, M. T. Firpo, and R. J. Akhurst (2006)
J. Cell Sci. 119, 759-768
   Abstract »    Full Text »    PDF »
Hedgehog signaling is essential for endothelial tube formation during vasculogenesis.
S. A. Vokes, T. A. Yatskievych, R. L. Heimark, J. McMahon, A. P. McMahon, P. B. Antin, and P. A. Krieg (2004)
Development 131, 4371-4380
   Abstract »    Full Text »    PDF »
Nitric oxide modulates murine yolk sac vasculogenesis and rescues glucose induced vasculopathy.
A. K. Nath, J. Enciso, M. Kuniyasu, X.-Y. Hao, J. A. Madri, and E. Pinter (2004)
Development 131, 2485-2496
   Abstract »    Full Text »    PDF »
Investigation into a role for the primitive streak in development of the murine allantois.
K. M. Downs, E. R. Hellman, J. McHugh, K. Barrickman, and K. E. Inman (2004)
Development 131, 37-55
   Abstract »    Full Text »    PDF »
Endoderm is required for vascular endothelial tube formation, but not for angioblast specification.
S. A. Vokes and P. A. Krieg (2002)
Development 129, 775-785
   Abstract »    Full Text »    PDF »
A transitional stage in the commitment of mesoderm to hematopoiesis requiring the transcription factor SCL/tal-1.
S. Robertson, M Kennedy, J. Shannon, and G Keller (2000)
Development 127, 2447-2459
   Abstract »    PDF »
Stem Cell Emergence and Hemopoietic Activity Are Incompatible in Mouse Intraembryonic Sites.
I. Godin, J. A. Garcia-Porrero, F. Dieterlen-Lievre, and A. Cumano (1999)
J. Exp. Med. 190, 43-52
   Abstract »    Full Text »    PDF »
Manipulation of the angiopoietic/hemangiopoietic commitment in the avian embryo.
L Pardanaud and F Dieterlen-Lievre (1999)
Development 126, 617-627
   Abstract »    PDF »
Hematopoietic induction and respecification of A-P identity by visceral endoderm signaling in the mouse embryo.
M Belaoussoff, S. Farrington, and M. Baron (1998)
Development 125, 5009-5018
   Abstract »    PDF »
Vascularization in the murine allantois occurs by vasculogenesis without accompanying erythropoiesis.
K. Downs, S Gifford, M Blahnik, and R. Gardner (1998)
Development 125, 4507-4520
   Abstract »    PDF »
Cell autonomous functions of the receptor tyrosine kinase TIE in a late phase of angiogenic capillary growth and endothelial cell survival during murine development.
J Partanen, M. Puri, L Schwartz, K. Fischer, A Bernstein, and J Rossant (1996)
Development 122, 3013-3021
   Abstract »    PDF »
Two distinct endothelial lineages in ontogeny, one of them related to hemopoiesis.
L Pardanaud, D Luton, M Prigent, L. Bourcheix, M Catala, and F Dieterlen-Lievre (1996)
Development 122, 1363-1371
   Abstract »    PDF »
Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro.
C Soudais, M Bielinska, M Heikinheimo, C. MacArthur, N Narita, J. Saffitz, M. Simon, J. Leiden, and D. Wilson (1995)
Development 121, 3877-3888
   Abstract »    PDF »
Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice.
M. Dickson, J. Martin, F. Cousins, A. Kulkarni, S Karlsson, and R. Akhurst (1995)
Development 121, 1845-1854
   Abstract »    PDF »
Hypoblastic tissue and fibroblast growth factor induce blood tissue (haemoglobin) in the early chick embryo.
C Gordon-Thomson and B. Fabian (1994)
Development 120, 3571-3579
   Abstract »    PDF »
flk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors.
T. Yamaguchi, D. Dumont, R. Conlon, M. Breitman, and J Rossant (1993)
Development 118, 489-498
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)