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Science 26 March 1965:
Vol. 147. no. 3665, pp. 1581 - 1583
DOI: 10.1126/science.147.3665.1581
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Articles

Glycerinated Skeletal and Smooth Muscle: Calcium and Magnesium Dependence

Ronald S. Filo 1, David F. Bohr 1, and J. C. Ruegg 2

1 Department of Physiology, University of Michigan, Ann Arbor
2 Max-Planck Institute, Heidelberg, Germany

Contractions of glycerinated skeletal (striated) and vascular (smooth) muscles are similar in their calcium dependence but differ in their magnesium dependence. The threshold concentration of free Ca++ for contraction of either muscle was 1.8 x 10-7M; maximum tension developed when the concentration of free Ca++ was slightly greater than 10-6M. The Mg concentration required for contraction of smooth muscle was at least ten times as great as that for skeletal muscle.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)