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Science 12 March 1965:
Vol. 147. no. 3663, pp. 1307 - 1308
DOI: 10.1126/science.147.3663.1307
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Articles

Bursa of Fabricius in Chickens: Possible Humoral Factor

Ronald L. St. Pierre 1 and G. Adolph Ackerman 1

1 Department of Anatomy, Ohio State University, College of Medicine, Columbus

Chicks bursectomized by testosterone injection on the 5th day of incubation showed a marked inability to produce antibodies to Salmonella typhimurium. When portions of the bursa of Fabricius were enclosed in cell-impermeable Millipore diffusion chambers and implanted subcutaneously or intraperitoneally, the antibody-producing capacity of these animals was restored. Evidence strongly suggests that the bursa of Fabricius elaborates a non-cellular agent capable of restoring immunologic reactivity in bursectomized chicks.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Lymphocyte-differentiating hormone of bursa of fabricius.
A Brand, D. Gilmour, and G Goldstein (1976)
Science 193, 319-321
   Abstract »    PDF »
Restoration of Gamma Globulin Production in Agammaglobulinemic Chickens.
M. D. Cooper, M. L. Schwartz, and R. A. Good (1966)
Science 151, 471-473
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)