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Science 12 March 1965:
Vol. 147. no. 3663, pp. 1304 - 1305
DOI: 10.1126/science.147.3663.1304
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Articles

Immunoglobulin Structure: Amino- and Carboxyl-Terminal Peptides of Type I Bence Jones Proteins

Koiti Titani 1 and Frank W. Putnam 1

1 Department of Biochemistry, University of Florida, Gainesville

Analysis of the amino acid sequence in Bence Jones proteins permits study of the structure of L-chains of normal immunoglobulins. An amino-terminal octadecapeptide containing the sole methionine residue occurs in many but not all immunoglobulins of antigenic type I. The carboxyl-terminal octapeptide appears invariant in type I proteins and ends in cysteine, which may have a cross-linking function.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Studies of Monoclonal Immunoglobulins (M-Components) in Various Kindreds.
R. C. WILLIAMS JR., J. L. ERICKSON, H. F. POLESKY, and W. R. SWAIM (1967)
Ann Intern Med 67, 309-327
   Abstract »    PDF »
Structure and Evolution of Kappa and Lambda Light Chains.
F. W. Putnam, K. Titani, M. Wikler, and T. Shinoda (1967)
Cold Spring Harb Symp Quant Biol 32, 9-29
   Abstract »    PDF »
Antigenic Determinants Common to Human Immunoglobulins G and M: Importance of Conformational Antigens.
M. Seligmann, C. Miaesco, and G. Meshaka (1966)
Science 154, 790-791
   Abstract »    PDF »
Biosynthesis of Gamma Globulin: Studies in a Cell-Free System.
K. H. Stenzel and A. L. Rubin (1966)
Science 153, 537-539
   Abstract »    PDF »
Immunoglobulin Structure: Variation in the Sequence of Bence Jones Proteins.
K. Titani, E. Whitley Jr., and F. W. Putnam (1966)
Science 152, 1513-1516
   Abstract »    PDF »
Immunoglobulin Structure: Partial Amino Acid Sequence of a Bence Jones Protein.
K. Titani, E. Whitley Jr., L. Avogardo, and F. W. Putnam (1965)
Science 149, 1090-1092
   Abstract »    PDF »


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