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Science 5 March 1965:
Vol. 147. no. 3662, pp. 1153 - 1154
DOI: 10.1126/science.147.3662.1153
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Articles

Carcinogenic Aromatic Hydrocarbons: Special Vulnerability of Rats

Charles B. Huggins 1, Elizabeth Ford 1, and E. V. Jensen 1

1 Ben May Laboratory for Cancer Research, University of Chicago, Chicago

Compared with other species, the rat is unusually vulnerable to polynuclear aromatic hydrocarbons. In the rat, relatively small amounts of carcinogenic aromatics (i) profoundly depress incorporation of thymidine in DNA, (ii) greatly induce menadione reductase in liver, and (iii) then kill the rat.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Breast Tumor Incidence in Rats After Partial Mammary Resection.
T. W. Klamer, W. L. Donegan, and M. H. Max (1983)
Arch Surg 118, 933-935
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Endocrine-Induced Regression of Cancers.
C. Huggins (1967)
Science 156, 1050-1054
   Abstract »    PDF »
Rat Mammary Gland RNA: Incorporation of C14-Formate and Effect of Hormones and 7,12-Dimethylbenz[alanthracene.
P. R. Libby and T. L. Dao (1966)
Science 153, 303-305
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)