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Science 26 February 1965:
Vol. 147. no. 3661, pp. 1036 - 1037
DOI: 10.1126/science.147.3661.1036
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Articles

Botulinum Toxin, Type A: Effects on Central Nervous System

E. H. Polley 1, J. A. Vick 1, H. P. Ciuchta 1, D. A. Fischetti 1, F. J. Macchitelli 1, and N. Montanarelli 1

1 Neurology Branch, Experimental Medicine Division, Directorate of Medical Research, U.S. Army Edgewood Arsenal Chemical Research and Development Laboratories, Edgewood Arsenal, Maryland 21010

This study has demonstrated that type A botulinum toxin has a depressant effect on the cortical electrical activity of anesthetized and unanesthetized monkeys. Simultaneous recordings of vital signs indicated a relative lack of change in the electrocardiogram, respiration, blood pressure, and heart rate during this time. The change in the electroencephalogram appeared cyclic in nature and independent of dose or time. All animals exhibited signs of respiratory failure characterized by a gradual interference with neuromuscular transmission at the diaphragm, and subsequently died an anoxic death.


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