Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 19 February 1965:
Vol. 147. no. 3660, pp. 873 - 879
DOI: 10.1126/science.147.3660.873
Prev | Table of Contents | Next

Articles

Contact-Induced Cytotoxicity by Lymphoid Cells Containing Foreign Isoantigens

Erna Möller 1

1 Department of Tumor Biology, Karolinska Institutet Medical School, Stockholm 60, Sweden

In tissue culture, immune lymph node cells containing foreign histocompatibility antigens of the H-2 type exert marked cytotoxic effects on tumor cells incompatible with the H-2 antigen. An equally pronounced effect is obtained when normal allogeneic and semi-isologous lymphoid cells of F1 hybrids are caused to aggregate around the target tumor cells by treating the cultures with either heat-inactivated rabbit antiserum to mouse cells or phytohemagglutinin. Isologous lymph node cells have no effect. Thus, aggregation of lymphoid cells and target cells is a necessary but insufficient requirement for cytotoxicity in vitro; in addition, close contact must be established between histoincompatible cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Recent Advances in Chronic Granulomatous Disease.
J. I. GALLIN, E. S. BUESCHER, B. E. SELIGMANN, J. NATH, T. GAITHER, and P. KATZ (1983)
Ann Intern Med 99, 657-674
   Abstract »    PDF »
Graft Rejection.
J. D. Feldman (1969)
Arch Intern Med 123, 713-718
   Abstract »    PDF »
Noncycling Tumor Cells: Mitogenic Response to Antilymphocytic Serum.
J. J. DeCosse and S. Gelfant (1968)
Science 162, 698-699
   Abstract »    PDF »
Cytotoxic Action of Stimulated Lymphocytes on Allogenic and Autologous Erythrocytes.
P. Perlmann, H. Perlmann, and G. Holm (1968)
Science 160, 306-309
   Abstract »    PDF »
Cell-Bound Immunity to Autologous and Syngeneic Mouse Tumors Induced by Methylcholanthrene and Plastic Discs.
I. Hellstrom and K. E. Hellstrom (1967)
Science 156, 981-983
   Abstract »    PDF »
Chromosomal Breakage Induced by Extracts of Human Allogeneic Lymphocytes.
P. J. Fialkow (1967)
Science 155, 1676-1677
   Abstract »    PDF »
Local Recognition of Histocompatibility Differences in Skin Grafts.
P. B. Lambert and H. A. Frank (1967)
Science 155, 99-101
   Abstract »    PDF »
Abrogation of Allogeneic Inhibition by Cortisone.
K. E. Hellstrom, I. Hellstrom, and G. Haughton (1965)
Science 149, 82-84
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)