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Science 19 February 1965:
Vol. 147. no. 3660, pp. 869 - 870
DOI: 10.1126/science.147.3660.869
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Articles

Glycoprotein Biosynthesis in Human Reticulocytes: A Lesion in Thalassemia

Edwin H. Eylar 1 and Gastone T. Matioli 1

1 Departments of Biochemistry and Microbiology, University of Southern California School of Medicine, Los Angeles

The rate of incorporation of glucosamine into the glycoprotein of reticulocyte stroma is greatly increased in thalassemia. This increase suggests a major enzymic disorder in the buildup of cellular membrane and reconciles the accumulation of material showing a positive reaction with periodic acid Schiff reagent with the clinical picture of oligocythemia and microcytosis.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)