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Science 5 February 1965:
Vol. 147. no. 3658, pp. 617 - 619
DOI: 10.1126/science.147.3658.617
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Articles

Antibodies against the Component Polypeptide Chains of Bovine Insulin

Yasuo Yagi 1, Patricia Maier 1, and David Pressman 1

1 Department of Biochemistry Research, Roswell Park Memorial Institute, New York State Department of Health, Buffalo 3

Antibodies were produced in guinea pigs against A and B chains of bovine insulin; the chains were prepared by cleavage of all the disulfide bonds with sulfite. Antibodies against A chain reacted with A chain, but not with B chain or native insulin. Antibodies against B chain reacted strongly with both B chain and insulin, but not with A chain. Antibodies against insulin reacted strongly with insulin, weakly with B chain, and not at all with A chain. The results indicate that the insulin-reactive antibodies in antiserums to B chain and to insulin differ and are directed to differing individual antigenic regions of the insulin molecule.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Recent Advances Relative to Diabetes Mellitus.
R. H. WILLIAMS (1965)
Ann Intern Med 63, 512-529
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