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Science 5 February 1965:
Vol. 147. no. 3658, pp. 613 - 615
DOI: 10.1126/science.147.3658.613
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Articles

Polypeptide Chains of Antibody: Effective Binding Sites Require Specificity in Combination

O. A. Roholt 1, G. Radzimski 1, and D. Pressman 1

1 Roswell Park Memorial Institute, New York State Department of Health, Buffalo 3

Separated chains from antibody of different rabbits do not always give effective binding sites although combination of the chains does occur. There is a specificity of combination such that only chains from the same (or perhaps a related) rabbit form effective binding sites. There appears to be preferential combination between those chains which yield effective sites.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Summary: Waiting for the End.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)